the area by the small boat harbor and down to hampton bar will produce some bigguns. use bloodworms, the fake stuff works too. but they will eat almost anything. a good hotspot is near petersons yacht basin, find the drop off where its about 15-20 ft and you should fill up the cooler quickly, by the ammunition peir is good to. good luck
on the Hampton side of the river between the Hampton Roads Bridge Tunnel and the Monitor Merrimack.
another area that can be very good early in the year is near the Lion's Bridge. If you put in at Huntington Park it's about a mile up the river on the Newport News side. Look for all the floating wrecks from north carolina "releasing" every singe fish into their coolers. Early in the season the fish seem to like shallower water i guess because of the heat from the sun.